The express and clinical significance of Trefoil factor 3 in patients with gastrointestinal failure of postoperation after esophageal cancer

VernacularTitle:肠三叶因子在食管癌术后胃肠道功能衰竭时的表达及临床意义
Author: Minjie MA ¹ ; Shangqing XU ; Chang CHEN ; Biao HAN
Author Information

1. 730000,兰州大学第一医院胸外科
Keywords: Trefoil factor 3; Esophageal cancer; Gastrointestinal failure
From: Chinese Journal of Thoracic and Cardiovascular Surgery 2018;34(6):366-369
CountryChina
Language:Chinese
Abstract: Objective To evaluate the relationship between the Trefoil factor 3 (TFF3) serum,concentration and gastrointestinal failure(GIF) and discuss eaely diagnosis,treatment and prognosis in patients with GIF after esophageal cancer surgery.Methods To test the TFF3 levels of the serum during the postoperation of esophageal cancer by ELISA.Results Serum TFF3 concentrations measured prior to the occurrence of GIF were significantly higher than in control group (P ＜ 0.01).serum TFF3 concentration was significantly related to gastrointestinal tract function score(r =-0.712).Cox proportional hazards model analysis showed that the serum TFF3 concentrations at the time of occurrence of gastrointestinal failure,and 48 hours later,could be used as prognostic factors in critically ill pediatric patients with GIF(r =1.443 and 1.872,respectively).Conclusion TFF3 may play an important role in predicting GIF in pediatric critical illness and has a protective function in the mucosal repair process.