The long-term impact of postoperative pulmonary complication after resection of non-small cell lung cancer
10.3760/cma.j.issn.1001-4497.2017.12.001
- VernacularTitle:胸腔镜肺癌根治术后肺部并发症对远期预后的影响
- Author:
Shao-Dong WANG
1
;
Xizhao SUI
;
Xiao LI
;
Yun LI
;
Jianfeng LI
;
Guanchao JIANG
;
Jun LIU
;
Jun WANG
Author Information
1. 100044,北京大学人民医院胸外科
- Keywords:
Lung neoplasms;
Thoracoscopy;
Postoperative complication
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2018;34(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the long-term impacts of major pulmonary complications ( MPCs) and identify the in-dependent risk factors in those non-small cell lung cancer(NSCLC)patients who underwent VATS lobectomy.Methods A ret-rospective study was developed to analyze the pulmonary complications of 574 non-small cell lung cancer patients who under-went VATS lobectomy in Peking University Hospital , the complications were graded according to TMM classification criteria . The effects of PCs on the long-term prognosis were analyzed by using the Kaplan-Meier method.Multivariate logistic regression analysis was used to determine the risk factors of MPCs.Results Of 574 patients, 106 had PCs, including 50(8.7％) MPCs, Postoperative pulmonary complications were associated with significantly longer drainage time (P<0.001) and hospital stays(P<0.001).Perioperative mortality was significantly increased in patients with PCs (4.0％ vs 0.6％; P =0.021). Those who develop a MPC had a reduced 3-year DFS and 5-year DFS(61.3％ vs.77.4％、42.2％ vs.69.3％;P=0.003), as well as the reduced 3-year OS and 5-year OS(78.5％vs.88.2％、62.4％ vs.79.2％;P=0.047).MPCs were independ-ent prognostic factors of patients with lung cancer .Multivariate logistic regression analysis showed that the independent risk fac-tors for MPCs were age, male, ASA grade.Conclusion Major pulmonary complications after VATS lobectomy are associated with a poorer long-time outcome.The independent risk factors for MPCs are age, male, and ASA grade.
