Microsurgical treatment of solitary fibrous tumor in the central nervous system
10.3760/cma.j.issn.1001-2036.2018.02.002
- VernacularTitle:中枢神经系统孤立性纤维瘤的显微外科手术治疗
- Author:
Daling DING
1
;
Jianrui SUN
;
Shukai WANG
;
Xianzhi LIU
;
Changhe PANG
Author Information
1. 郑州大学第一附属医院神经外科
- Keywords:
Solitary fibrous tumor;
Central nervous system;
Immunohistochemical staining;
Microsurgical operation
- From:
Chinese Journal of Microsurgery
2018;41(2):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinicopathological features,imaging manifestation and treatment of solitary fibrous tumor in the central nervous system(cSFT),in order to improve the diagnosis and treatment.Methods Fourteen cases of cSFT that had been received microsurgery treatment from June,2010 to July,2016 were analyzed retrospectively.The clinicopathological features,treatment and prognosis were concluded and analyzed.Results In 14 patients with cSFT treated with microsurgery,and 1 case in the foramen magnum region for the first time,and enriched the understanding of this disease.Of 14 patients with cSFT,12 received total resection and 2 subtotal or part.The cSFT were pathologically diagnosed as benign tumors in 11 patients and low grade cSFT in 3.The microscopical presence of spindle-shaped tumor cells arranged in fascicles that alternate hypocellular and hypercellular areas separated from each other by collagenous fibre.Immunohistochemistry was positive for Vimentin,and CD34,Bcl-2 of 14 patients,and positive for CD99 in 12 patients.Followed-up time was from 6 to 49 months.Twelve cases had good prognosis to total resection and 2 recurrence due to subtotal or part resection.Conclusion cSFT is extremely rare,and it has some characteristics on MRI,final diagnosis should be depended on pathological and immunohistochemical examination.There are good prognoses in the patients with cSFT after the total removal of cSFT,but when the lesion could not be totally resected,radiotherapy should be considered,the curative effect of chemotherapy on cSFT is not definitive.