Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA.
- Author:
Yunkyoung LEE
1
Author Information
- Publication Type:In Vitro ; Review
- Keywords: Conjugated linoleic acid (CLA); 9E,11E-CLA; anti-inflammatory; isomer-specificity
- MeSH: Colonic Neoplasms; Endothelial Cells; Linoleic Acid; Linoleic Acids, Conjugated; Macrophages; Models, Animal; Sensitivity and Specificity*
- From:Nutrition Research and Practice 2008;2(4):326-330
- CountryRepublic of Korea
- Language:English
- Abstract: Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.
