Clinical value of carbon nanoparticles marker for neoadjuvant chemoradiotherapy of rectal cancer
10.3760/cma.j.issn.1007-5232.2018.09.007
- VernacularTitle:内镜纳米炭标记对直肠癌新辅助放化疗疗效判断及手术的价值
- Author:
Haitao LI
1
;
Yan LIN
;
Wen WANG
;
Rong WANG
;
Guanpo ZHANG
Author Information
1. 解放军福州总医院 厦门大学附属东方医院 福建医科大学福总临床医学院消化内科
- Keywords:
Colorectal neoplasms;
Antineoplastic combined chemotherapy protocols;
Carbon nanoparticles;
Tumor markers
- From:
Chinese Journal of Digestive Endoscopy
2018;35(9):634-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of carbon nanoparticles marker before neoadjuvant chemoradiotherapy ( NACRT) of locally advanced rectal cancer. Methods Clinical data of 18 patients ( 11 male and 7 female) with locally advanced rectal cancer admitted to Fuzhou General Hospital from July 2015 to December 2015 was analyzed retrospectively. Patients were 45. 8±12. 5 (35-68) years old. Before NACRT, carbon nanoparticles were injected through an endoscope. The multiple-point injection was 1 cm from the lesion ( 4 quadrants of the upper, lower, left and right) to avoid direct injection into the tumor. The injection suspension of carbon nanoparticles was 5 mg per point. After endoscopic marking, the duration of NACRT plus rest was 8 ± 2 ( 5-11 ) weeks, and then the surgery was performed. Effects of endoscopic carbon nanoparticles markers on judgment of the tumor size, the distance from the lower margin of the tumor to the anal border, the intraoperative condition and the rate of anus preservation were observed. Results The operation time was 10. 0±3. 5(5-15)min. No adverse reactions, and bleeding, perforation or other complications occurred. After NACRT, all tumors were reduced, completely disappeared in 7 cases ( 38. 9％) , and pathologically respond in 6 cases ( 33. 3％) . The distance between the lower margin of the tumor and the margin of the anal border was 6. 4 ± 1. 8 ( 4. 5-10. 0) cm. In the operation, 100％ lesions were found to be stained black outside the intestine, with clear location and partial lymph node dysphasia. Eight cases received anus preserving operation, and the rate of anus preservation was 44. 4％. Conclusion The carbon nanoparticles marker can accurately position the tumor and label the lymph node for locally advanced rectal cancer before NACRT. The dyeing effect is lasting, conducive to the surgery or follow-up observation.
