Curative effect analysis of endoscopic submucosal dissection on the synchronous multiple primary early cancers in esophagus and stomach
10.3760/cma.j.issn.1007-5232.2018.06.007
- VernacularTitle:食管胃同时性双原发早期癌或癌前病变内镜黏膜下剥离术疗效分析
- Author:
Qiang SHI
1
;
Pinghong ZHOU
;
Yunshi ZHONG
;
Meidong XU
;
Zhipeng QI
;
Bing LI
;
Shilun CAI
;
Tao CHEN
;
Di SUN
;
Liqing YAO
Author Information
1. 复旦大学附属中山医院内镜中心 上海消化内镜诊疗工程技术研究中心
- Keywords:
Neoplasms,multiple primary;
Early gastric cancer;
Early esophageal cancer;
Endoscopic submucosal dissection
- From:
Chinese Journal of Digestive Endoscopy
2018;35(6):410-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility, safety and effectiveness of endoscopic submucosal dissection ( ESD) in the treatment of the synchronous multiple early cancer or precancerous lesions in esophageal and stomach. Methods A retrospective study was conducted on the data of 5 patients with synchronous multiple early cancer or precancerous lesions in esophageal and stomach who were treated by ESD in Endoscopy Center of Zhongshan Hospital from January 2008 to December 2013. The characteristics of lesions, and results of therapy and follow-up were analyzed. Results All 5 patients were male with mean age of 67. 8±13. 1 years. The mean size of esophageal lesions was 2. 1±0. 9 cm with 1 lesion located in the upper esophagus and 4 in the middle. The mean size of gastric lesions was 2. 5±1. 5 cm with 2 lesions in the antrum, 2 in the gastric angle and 1 in cardia. Lesions in 4 cases were removed at the same time and 1 at different times. All lesions achieved complete resection. Postoperative pathological results showed that there were 2 cases of esophageal precancerous lesions with gastric precancerous lesions, 2 cases of esophageal precancerous lesions with early gastric cancer, and 1 case of early esophageal cancer with early gastric cancer. The 5 patients with 10 lesions all achieved curative resection. Postoperative esophageal stricture occurred in 1 case, which was improved after dilation. Median follow-up time was 72 months, when 3 patients survived and 2 patients died. However, the cause of death was not associated with the treatment. Conclusion ESD is a minimally invasive endoscopic method for treating synchronous multiple primary early cancers in esophagus and stomach.
