A meta-analysis of contrast-enhanced harmonic endoscopic ultrasonography on differential diagnosis of pancreatic mass
10.3760/cma.j.issn.1007-5232.2018.03.010
- VernacularTitle:谐波造影增强内镜超声检查对胰腺占位良恶性鉴别的Meta分析
- Author:
Yang LI
1
;
Yirong WU
;
Yefei ZHANG
;
Min XU
Author Information
1. 南京医科大学附属上海市第一人民医院消化内科
- Keywords:
Endoscopic ultrasonography;
Contrast-enhanced harmonic;
Pancreatic neoplasms;
Diagnosis;
Meta-analysis
- From:
Chinese Journal of Digestive Endoscopy
2018;35(3):195-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the value of contrast-enhanced harmonic endoscopic ultrasonography(CEH-EUS)on differential diagnosis of pancreatic mass. Methods Multiple Chinese and English databases were retrieved to selected relevant literature.The quality of literature was assessed,and the data were meta-analyzed using Metadisc 1.4 and STATA 14.0 software. Results A total of 16 researches with 1 352 patients were included. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio,and diagnostic odds ratio was 93%(95%CI: 92%-95%), 84%(95%CI:80%-87%), 5.82(95%CI: 4.06-8.33), 0.08(95%CI: 0.06-0.10), and 77.33(95%CI: 52.37-114.17), respectively. The area under the summary receiver operating characteristic curve was 0.96(95%CI: 0.94-0.97). The results of subgroup analysis demonstrated that the number of cases, region, QUADAS scores, the diameter and type of mass,and the experience of diagnostician were not the source of heterogeneity.After 2 articles with larger bias were eliminated,the heterogeneity dropped to an acceptable range,and the pooled sensitivity,specificity,positive predictive value and negative predictive value had no significant change. All these suggested that the results of meta-analysis were reliable. Conclusion CEH-EUS has a high accuracy in differential diagnosis of pancreatic mass,and can be used as an effective diagnostic method.
