Risk factors of canceration for intestinal?type gastric adenoma
10.3760/cma.j.issn.1007-5232.2018.02.007
- VernacularTitle:肠型胃腺瘤癌变的危险因素分析
- Author:
Lamei TENG
1
;
Qingwei ZHANG
;
Xintian ZHANG
;
Ying ZHOU
;
Xiaobo LI
Author Information
1. 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所
- Keywords:
Risk factors;
Stomach diseases;
Intestinal?type gastric adenoma;
Intestinal?type gastric adenocarcinoma
- From:
Chinese Journal of Digestive Endoscopy
2018;35(2):110-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the potential risk factors of canceration for intestinal?type gastric adenoma. Methods A retrospective study were performed on the data of 142 intestinal?type gastric adenoma patients who underwent endoscopic resection and was confirmed by postoperative histopathology at Digestive Endoscopy Centre, Shanghai Renji Hospital from May 2012 to December 2016. Potential risk factors for canceration of intestinal?type gastric adenoma were analyzed using univariate and multivariate Logistic analysis. Results A total of 142 intestinal?type gastric adenomas from 142 patients were collected in the study,comprised of 124 noncancerous lesions(low grade intraepithelial neoplasia)and 18 cancerous lesions (high grade intraepithelial neoplasia or carcinoma). Age 65 and older(P=0.03, OR=3.37, 95%CI:1.10?10.29),size equal or greater than 2 cm(P= 0.04, OR= 3.93, 95%CI: 1.07?14.49), and Helicobacter Pylori infection(P=0.04,OR=3.60,95%CI:1.07?12.14)were significantly associated with canceration in the univariate Logistic regression analysis. In the multivariate regression analysis,age 65 and older(P=0.03,OR=4.36,95%CI:1.17?16.24),size equal or greater than 2 cm(P=0.02,OR=5.79, 95%CI:1.28?26.12),and Helicobacter Pylori infection(P=0.03,OR=3.89,95%CI:1.15?13.59)were independent risk factors of canceration. Conclusion Intestinal?type gastric adenoma has varying degrees of intraepithelial neoplasia. Patient who is 65 years or older, or with Helicobacter Pylori infection, and lesion diameter of more than 2 cm are the potential risk factors of carceration.
