Efficiency and safety of endoscopic submucosal dissection for patients with rectal neuroendocrine neoplasm
10.3760/cma.j.issn.1007-5232.2018.01.005
- VernacularTitle:内镜黏膜下剥离术治疗直肠神经内分泌肿瘤的疗效及安全性分析
- Author:
Yuan TIAN
1
;
Long RONG
;
Weidong NIAN
;
Yunlong CAI
;
Jinyu LIANG
;
Yan HE
Author Information
1. 北京大学第一医院内镜中心
- Keywords:
Neuroendocrine tumors;
rectum;
Endoscopic submucosal dissection;
Therapy;
Efficiency;
Safety
- From:
Chinese Journal of Digestive Endoscopy
2018;35(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficiency and safety of endoscopic submucosal dissection (ESD)for rectal neuroendocrine neoplasm(NEN). Methods A retrospective analysis was performed on data collected from 58 consecutive patients with rectal NEN,who underwent endoscopic ultrasonography and followed by ESD from January 2006 to January 2016 at Peking University First Hospital. Patients′endoscopic and pathological features, clinical manifestations, R0 resection rate and follow-up results were studied. Results En bloc resection was achieved for all of the 58 lesions with a mean diameter of 7.6 mm(range 3.0-18.0 mm). The complete resection rate was 94.8%(55/58). One patient showed postoperative bleeding. The diameter of lesion more than 15 mm increased the risk of non-R0 resection(P<0.05). During the mean follow-up of 3.2 years(range 1.2-11.2 years), all patients remained free from local recurrence. However,distant metastasis was detected in 1 NEN G2 patient with lymphatic invasion(1.7%). Conclusion ESD is effective for treatment of rectal NEN with diameter less than 15 mm and causes less complications. Tumor features and stage determine the risk of distant metastasis,so long-term follow-up is essential.
