Distribution and antibiotic resistance of 532 bacterial panthogens in blood culture in a hematology de-partment
10.3760/cma.j.issn.0254-5101.2018.11.010
- VernacularTitle:532株血液科血培养主要病原菌分布及药物敏感性分析
- Author:
Xue LIU
1
;
Fei JIN
;
Wenying XIA
;
Fang NI
;
Yaning MEI
Author Information
1. 221006,徐州医科大学第二附属医院检验科
- Keywords:
Blood culture;
Pathogenic bacteria;
Antibiotic;
Antimicrobial susceptibility
- From:
Chinese Journal of Microbiology and Immunology
2018;38(11):862-865
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution and antibiotic resistance of bacterial pathogens in blood culture in the Department of Hematology of the First Affiliated Hospital of Nanjing Medical Universi-ty from 2013 to 2017. Methods BACTEC FX automatic blood culture instrument was used for blood cul-ture. VITEK-2 Compact automatic microbial identification and drug susceptibility system was used for bacte-rial identification, drug sensitivity testing and fungal identification. K-B and ATB FUNGUS 3 methods were used for Streptococcus and fungi susceptibility testing, respectively. WHONET5. 6 software was used for sta-tistical analysis. Results The positive results of blood culture accounted for 7. 6% during 2013 to 2017 and the top five isolated pathogenic bacteria were Escherichia coli (20. 9% ), Klebsiella pneumoniae (18. 0% ), coagulase negative Staphylococcus (12. 4% ), Pseudomonas aeruginosa (11. 5% ) and Enterobacter cloacae (3. 6% ). Carbapenems (94. 4% ) were the most active antibiotics against Enterobacteriaceae. Pseudo-monas aeruginosa strains were sensitive to all antibacterial dugs except aztreonam. Acinetobacter baumannii strains had a lower sensitivity to almost all antibacterial dugs. Vancomycin, linezolid and teicoplanin were active antimicrobial agents against gram-positive cocci. Conclusion Patients with hematological diseases are more susceptible to nosocomial infection, which should be paid more attention to in clinical and laborato-ry practice. Rational antimicrobial therapy is an effective way for control of antimicrobial resistance.
