Advances in pertussis toxin detoxification
10.3760/cma.j.issn.0254-5101.2018.10.013
- VernacularTitle:百日咳毒素脱毒的研究进展
- Author:
Shuyang GUO
1
;
Xin YAO
;
Jianhui LUO
Author Information
1. 国家药品监督管理局药品审评中心
- Keywords:
Pertussis toxin;
Detoxification;
Safety;
Immunogenicity
- From:
Chinese Journal of Microbiology and Immunology
2018;38(10):796-800
- CountryChina
- Language:Chinese
-
Abstract:
Pertussis toxin (PT) is one of the major virulence factors of Borrelia pertussis and also an essential component of pertussis vaccines. Before using it in vaccine production, detoxification is necessa-ry because of its biological activity. This paper summarized the structure and detoxification process of PT as well as the safety and immunogenicity of pertussis vaccines prepared with detoxified PT.
