Research progress in broad neutralizing antibodies and universal vaccines against influenza A virus

VernacularTitle:抗A型流感病毒广谱中和抗体及广谱通用疫苗研究进展
Author: Daobin FENG ^{1
,

2} ; Mingbin LIU ; Xiaoyan ZHANG ; Jianqing XU
Author Information

1. 330006 南昌大学公共卫生学院流行病与卫生统计学系
2. 201508 上海,复旦大学附属公共卫生临床中心
Keywords: Influenza A virus; Heamagglutinin; Epitope; Broad neutralizing antibody; Vaccine
From: Chinese Journal of Microbiology and Immunology 2018;38(10):782-789
CountryChina
Language:Chinese
Abstract: Influenza vaccination is the most effective means to prevent and control influenza epi-demics, and the universal influenza vaccine which can induce broad and long-term protective effect is still in its infancy. Up to date, several broad neutralizing antibodies that can antagonize a variety of influenza A vi-ruses have been identified, and the crystal structure of the antibody and HA complex reveals at least three highly conserved epitopes. Deep insights into the molecular mechanism of the interactions between neutrali-zing antibodies and virus antigen can elicit a new strategy not only for rational design of universal influenza vaccines, but also for the development of antibody-based therapeutics against influenza virus. In this paper, advances in research of universal neutralizing antibodies and vaccines for Influenza A virus are reviewed.