Role of exosomes in virus infection

VernacularTitle:外泌体在病毒感染中的作用
Author: Guanghui ZHANG ¹ ; Jingchao REN ; Wu YAO ; Daokun YANG
Author Information

1. 河南省分子诊断与医学检验技术协同创新中心
Keywords: Exosomes; Virus; Infection; Role
From: Chinese Journal of Microbiology and Immunology 2018;38(6):476-480
CountryChina
Language:Chinese
Abstract: With the discovery of exosomes,new pathways of intercellular information and material exchange mediated by exosomes are attracting more and more attention from researchers. The process of exo-some production overlaps with many viral assembly and outflow pathways,suggesting that exosomes may be related to viral infections. In vitro experiments also show that exosomes play a very important role in viral in-fections. On one hand,exosomes can transfer viral nucleic acids and proteins,and may change microenviron-ment to promote the spread of infection. On the other hand,exosomes can induce immune responses by activa-ting antiviral pathways or transferring antiviral molecules. Do they promote or suppress the spread of infec-tion? What are the factors that affect their functions? In this paper,we review the role of exosomes in viral in-fection in order to provide a reference for better understanding the process of viral infection and immune re-sponses,and to provide a new train of thoughts for the prevention,diagnosis and treatment of viral diseases.