Genotypes of Treponema pallidum subspecies pallidum and their clinical significance
10.3760/cma.j.issn.0254-5101.2018.06.013
- VernacularTitle:梅毒螺旋体的基因分型与临床意义
- Author:
Jinquan LIU
1
;
Bufang XU
;
Wenlong HU
;
Qianqiu WANG
Author Information
1. 中国医学科学院 北京协和医学院皮肤病研究所
- Keywords:
Syphilis;
Genotype;
Serofast;
Drug resistance
- From:
Chinese Journal of Microbiology and Immunology
2018;38(6):468-471
- CountryChina
- Language:Chinese
-
Abstract:
With the development of genome sequencing technology,Treponema pallidum has been found to have different subspecies all around the world. It is widely recognized that Treponema pallidum could be subtyped by analyzing two or three target genes. Advances in molecular epidemiology of syphilis reveal that clinical characteristics of Treponema pallidum,such as virulence,serofast,drug resistance and the site of in-fection,are related to its subspecies. Specifically,14f/f may be more virulent;serofast may be more likely to happen in patients infected with Treponema pallidum of Tpr i genotype;A2058 and A2059 genes may be re-lated to resistance to macrolides. All these will be summarized in this review.
