Role of platelet in immunity and inflammation
10.3760/cma.j.issn.0254-5101.2018.04.012
- VernacularTitle:血小板参与免疫炎症反应的研究进展
- Author:
Xiaolong ZONG
1
;
Zhenyu LI
;
Yajun GU
;
Dianjun WEI
Author Information
1. 300211,天津医科大学第二医院检验科
- Keywords:
Platelet;
Innate immunity;
Inflammation;
Sepsis;
Atherosclerosis;
Antiplatelet therapy
- From:
Chinese Journal of Microbiology and Immunology
2018;38(4):313-320
- CountryChina
- Language:Chinese
-
Abstract:
Platelets are anuclear cell fragments derived from megakaryocytes, playing a critical role in hemostasis and thrombosis through adhesion,activation,release and aggregation. Antiplatelet therapy represents as the cornerstone of secondary prophylaxis of cardiovascular diseases. Increasing evidences sup-port the emerging role of platelets in innate immunity and inflammation and their involvement in the patho-physiological processes of sepsis, atherosclerosis, autoimmune diseases and tumors. Anti-inflammatory and anti-tumor effects of aspirin and P2Y12 receptor antagonist have been reported in clinical trials, suggesting that antiplatelet therapy may have a broad prospect in application. In this review,we focused on the molecu-lar mechanism of platelet involved in immunity and inflammation. In addition,recent findings of antiplatelet therapy for sepsis,atherosclerosis and tumors were discussed.
