Progress in plasmid-mediated colistin resistance gene mcr-1
10.3760/cma.j.issn.0254-5101.2018.04.011
- VernacularTitle:质粒介导的多黏菌素耐药基因mcr-1研究进展
- Author:
Xiangjun LIU
1
;
Yuan LYU
Author Information
1. 100034,北京大学第一医院临床药理研究所
- Keywords:
Colistin;
mcr-1;
plasmid;
Antimicrobial resistance
- From:
Chinese Journal of Microbiology and Immunology
2018;38(4):305-312
- CountryChina
- Language:Chinese
-
Abstract:
Colistin has been revalued as the last resort for multi-drug resistant gram-negative bacte-ria infections and attracted considerable attention. The plasmid-mediated colistin resistance gene mcr-1 was first reported in 2005,which not only altered our understanding of the mechanisms of colistin resistance,but also posed a significant threat to public health. Until now,mcr-1 has been reported in more than 30 countries and regions spreading over five continents. The whole world has paid high attention to mcr-1 and taken meas-ures to control the administration of colistin in order to contain the spread and dissemination of mcr-1. This review focused on the structure,epidemiology and molecular biological characteristics of mcr-1 and measures for the prevention of mcr-1 spreading,aiming at enhancing the recognition,prevention and control of mcr-1.
