Roles of CXC chemokine ligand 5(CXCL5) in dextran sulfate sodium(DSS)-induced inflammatory bowel disease in mice

VernacularTitle:CXCL5对DSS诱导的小鼠炎症性肠病的影响
Author: Jie SONG ¹ ; Yajie HU ; Jiaqi LI ; Yunguang HU ; Lei GUO ; Junjie MEI ; Longding LIU
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1. 650118昆明,中国医学科学院&北京协和医学院,医学生物学研究所,云南省重大传染病疫苗研发重点实验室
Keywords: Inflammatory bowel disease; CXC chemokine ligand 5; Inflammatory cytokine
From: Chinese Journal of Microbiology and Immunology 2018;38(3):187-192
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of CXC chemokine ligand 5 (CXCL5) in the patho-genesis of dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD). Methods A mouse model of IBD was established by giving 3% DSS in drinking water. Influences of CXCL5 knockout on mouse body weight, clinical symptoms, survival rate, pathological injury and the secretion of inflammatory cyto-kines were analyzed. Results CXCL5 levels in serum of mice with DSS-induced IBD were significantly higher than those of the normal control group. DSS-induced weight gain, death, pathological damages and inflammatory cytokine secretion were alleviated in mice after knocking out CXCL5. Conclusion CXCL5 might promote the secretion of inflammatory cytokines in mice with DSS-induced acute colitis and aggravate pathological damages,suggesting that CXCL5 might be a potentially important candidate target for the treat-ment of IBD.