Type Ⅶ secretion system in Mycobacteria
10.3760/cma.j.issn.0254-5101.2018.02.012
- VernacularTitle:分枝杆菌Ⅶ型分泌系统的研究进展
- Author:
Jiafang FU
1
;
Zhiyu WANG
;
Peipei ZHANG
;
Gongli ZONG
;
Guangxiang CAO
Author Information
1. 山东省医学科学院 山东省医药生物技术研究中心
- Keywords:
Mycobacteria;
Type Ⅶ secretion system;
Gene structure;
Secretion mechanism;
Pathogenicity
- From:
Chinese Journal of Microbiology and Immunology
2018;38(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Type Ⅶ secretion system(T7SS) is a novel and specialized secretion system discovered in recent years. It was first found in Mycobacterium tuberculosis. Type Ⅶ secretion system is involved in the secretion of virulence-associated proteins, the interaction between pathogens and hosts and the balance of zinc/iron ions. Moreover,it plays a critical role in the growth and pathogenesis of Mycobacteria. This review summarizes the components,substrates and translocation mechanisms of the type Ⅶ secretion system and its relation to the virulence of Mycobacteria aiming to provide references for developing novel strategies for disea-ses diagnosis,treatment and prevention.
