The influence of collateral circulation on the cognitive functioning of patients with severe unilateral carotid artery stenosis or occlusion
10.3760/cma.j.issn.0254-1424.2018.07.011
- VernacularTitle:单侧颈内动脉重度狭窄或闭塞后侧支循环开放对认知功能影响的经颅多普勒超声和P300研究
- Author:
Li FANG
1
,
2
;
Xiaoyi LI
;
Xicang SHAO
;
Ying HE
;
Yuzhu LI
;
Pan WANG
;
Jieqi LI
Author Information
1. 550002贵阳,贵州医科大学
2. 贵州省人民医院神经电生理中心
- Keywords:
Transcranial Doppler imaging;
P300;
Internal carotid artery;
Stenosis;
Occlusion;
Collateral circulation;
Cognitive impairment
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2018;40(7):521-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of collateral circulation on the cognition of persons with severe unilateral carotid artery stenosis or occlusion using transcranial Doppler (TCD) imaging combined with P300.Methods A total of 185 patients with stenosis or occlusion of the carotid artery were enrolled and randomly divided into a monocollateral group (n=83),a multicollateral group (n=79) and a noncollateral group (n=23).The monocollateral group was further divided into an anterior communicating artery (AcoA) group,an ophthalmic artery (OA)group and a post communicating artery (PcoA) group according to their collateral circulation.All patients and 40 normal controls (NC) were tested using the Montreal cognitive assessment (MoCA) and P300,and the correlation between the MoCA and P300 scores was analyzed.Results Compared with the NC group,all the other three groups had significantly lower average MoCA scores and P300 amplitudes.They also had significantly longer average P300 latency periods.Compared with the multicollateral group,both the monocollateral and noncollateral groups had significantly lower average MoCA scores and P300 amplitudes and longer P300 latencies.Comparing the monocollateral group with the noncoilateral group revealed the same trends.Among the monocollateral patients the average MoCA score of the AcoA group was significantly higher than the PcoA and OA group averages,while their average P300 latency period was significantly shorter and the amplitude significantly greater than the PcoA group's average.Correlation analyses showed that the MoCA score was negatively correlated with the P300 latency,but positively correlated with the P300 amplitude.Conclusions Collateral circulation can protect the cognitive function of patients with unilateral stenosis or occlusion of the internal carotid artery to some extent,with multicollateral circulation being more effective than monocollateral and AcoA circulation superior to both PcoA and OA circulation.The MoCA score is significantly correlated with the latency period of P300 in such cases.
