The effects of adrenergic and adrenergic blocking agents on the phosphorylase activity of bovine extraocular muscles.
- Author:
Byung Gook PAK
1
Author Information
1. Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:In Vitro ; Original Article
- MeSH:
Adrenergic Agents;
Adrenergic Antagonists*;
Epinephrine;
Isoproterenol;
Muscles*;
Norepinephrine;
Phenoxybenzamine;
Phosphorylase a;
Propranolol
- From:Journal of the Korean Ophthalmological Society
1972;13(1):11-16
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The author investigated the effect of adrenergic and adrenergic blocking agents on the phosphorylase activity of bovine extraocular muscle in vitro and obtained the following results: 1. The phosphorylase a activity of bovine extraocular muscle was revealed 53.6% in vitro. 2. The phosphorylase a activity of bovine extraocular muscle was slightly enhanced by the adrenergic agents such as epinephrine, norepinephrine and isoproterenol. 3. The phosphorylase a activity of bovine extraocular muscle was not affected by the adrenergic areceptor blocking agent, phenoxybenzamine but slightly inhibited by the adrenergic beta-receptor blocking agent, propranolol. 4. The phosphorylase a activity of bovine extraocular muscle previously treated with the adrenergic agents was blocked by a sole administration of propranolol or combined administrations of propranolol and phenoxybenzamine but not blocked by phenoxybenzamine alene.
