Advances in exosomal microRNA and pathogenesis of preeclampsia
10.3760/cma.j.issn.1007-9408.2018.09.010
- VernacularTitle:外泌体微小RNA与子痫前期发病机制的研究进展
- Author:
Xueya ZHAO
1
;
Xingyu YANG
;
Weiwei CHENG
Author Information
1. 200030,上海交通大学医学院附属国际和平妇幼保健院产科
- Keywords:
Pre-eclampsia;
Exosomes;
microRNAs
- From:
Chinese Journal of Perinatal Medicine
2018;21(9):622-625
- CountryChina
- Language:Chinese
-
Abstract:
Preeclampsia is an idiopathic gestational disease with unknown etiology or pathogenesis. Exosomes are membranous nanovesicles secreted by various cells, carrying contents such as proteins, mRNA, microRNA and lipids and being involved in regulations between cells by transporting the above contents through target cells. The expression of exosome-derived proteins and microRNAs in preeclampsia patients experiences changes, resulting in maternal inadequate trophoblast invasion, depressed endothelial cell function and angiogenesis. Research on placenta-derived exosomal microRNAs in preeclampsia patients may help to elucidate the pathogenesis of preeclampsia.
