Gut-microbiota-brain axis: implications and progress in neonatology
10.3760/cma.j.issn.1007-9408.2018.07.002
- VernacularTitle:肠道-微生物群-脑轴在新生儿医学研究中的意义和进展
- Author:
Dongli SONG
1
,
2
;
Laishuan WANG
Author Information
1. 美国加利福尼亚州圣塔克拉谷医疗中心新生儿科
2. 美国加利福尼亚州斯坦福大学医学院
- Keywords:
Gastrointestinal microbiome;
Dysbiosis;
Brain;
Growth and development
- From:
Chinese Journal of Perinatal Medicine
2018;21(7):435-441
- CountryChina
- Language:Chinese
-
Abstract:
Growing evidence from animal experiments and human epidemiological studies has revealed the intriguing communications between the gut,microbiota and brain,i.e.,the gut-microbiota-brain axis.The microbiota establishes its symbiotic rapport with the host early in life and participates in multiple developmental and physiological processes,including regulating brain development and influencing behavior and neurological function.Multiple perinatal factors influence neonatal colonization,and gut dysbiosis is a common finding in preterm infants.Perturbations in the delicate synergetic gut-microbiota-brain communication may have serious consequences,leading to abnormal brain development and long-term neurodevelopment disorders.
