Clinical outcomes of non-immune hydrops fetalis in the era of intrauterine intervention: a single centered retrospective analysis
10.3760/cma.j.issn.1007-9408.2018.01.003
- VernacularTitle:宫内干预时代下非免疫性胎儿水肿的临床结局:单中心回顾性研究
- Author:
Xing WEI
1
;
Gang ZOU
;
Yingjun YANG
;
Fenhe ZHOU
;
Jianping CHEN
;
Yan ZHOU
;
Luming SUN
Author Information
1. 201204 上海,同济大学附属第一妇婴保健院胎儿医学科 , 产前诊断中心
- Keywords:
Hydrops fetalis;
Pregnancy outcome;
Fetal therapies
- From:
Chinese Journal of Perinatal Medicine
2018;21(1):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pregnancy outcomes of non-immune hydrops fetalis (NIHF) in the era of intrauterine intervention. Methods We reviewed the medical records of 149 patients who were referred for NIHF and delivered at Fetal Medicine Unit, Shanghai First Maternity and Infant Hospital between March 2012 and March 2017. After systematic evaluation and consultation, 102 cases chose to terminate their pregnancies, 47 cases (31.5％) chose to continue their pregnancies, among which two cases were lost to follow-up. The rest 45 cases were divided into two groups according to whether they received intrauterine interventions or not, the intrauterine intervention group (n=18) and the control group (n=27), and the clinical characteristics and pregnancy outcomes were compared. Independent samples t-test or Kruskal-Wallis test, Chi-square test or Fisher exact test were applied for statistical analysis. Results The mean gestational age of the intervention group at diagnosis of NIHF was lower than that of the control group [26.5(23.4-30.0) weeks vs 30.3(29.0-32.0) weeks, χ2=7.427, P=0.006]. Compared with the control group, the intrauterine fetal death rate was slightly lower [25.9％(7/27) vs 1/18], the neonatal survival rate was slightly higher [37.0％(10/27) vs 11/18] in the intrauterine intervention group, although no statistically significance was observed (Fisher exact, P>0.05). In the intrauterine intervention group, the incidence of low Apgar score (<4) at both 1 and 5 min was 1/17 and 0/17, respectively, which was much lower than those of the control group [45％(9/20) and 35％(7/20), Fisher exact, both P<0.05]. Conclusions After overall prenatal evaluation, appropriate intrauterine interventions may improve the pregnancy outcomes in NIHF.
