Muscle mass evaluation and influential factors of sarcopenia in maintenance hemodialysis patients
10.3760/cma.j.issn.1001-7097.2018.10.003
- VernacularTitle:维持性血液透析患者肌肉量调查及相关因素分析
- Author:
Yiqi SONG
1
;
Li NI
;
Jiaying ZHANG
;
Chuhan LU
;
Yao YAO
;
Bihong HUANG
;
Qian ZHANG
;
Jing CHEN
Author Information
1. 复旦大学附属华山医院肾内科国家老年疾病临床医学研究中心
- Keywords:
Renal dialysis;
Sarcopenia;
Hand strength;
Muscle mass;
Protein energy wasting
- From:
Chinese Journal of Nephrology
2018;34(10):732-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the muscle mass in maintenance hemodialysis (MHD) patients and analyze the influential factors.Methods Ninety-seven patients on MHD and 34 healthy people were recruited.Muscle mass was measured by bioelectrical impedance analysis and compared.Patients'age,sex,height,body weight,walking activity,modified quantitative subjective global assessment (MQSGA) score and laboratory tests were recorded.The relationship of appendicular skeletal muscle mass/height2 (ASM/H2) and other factors were analyzed using multivariate linear regression.Results Compared with normal cohort,the MHD patients showed lower body fat rate and lower ASM/H2 (both P ＜ 0.05).In 97 MHD patients,21.4％ of male patients suffered from sarcopenia,and 24.4％ of female patients suffered from sarcopenia.Patients were divided into two groups according to the level of ASM/H2 (male ＜ 7.0 kg/m2,female ＜ 5.8 kg/m2).The grip strength,serum creatinine,1,25(OH)2D and mid-arm muscle circumference in low ASM/H2 group were lower than those in normal ASM/H2 group,and the differences were significant (all P ＜ 0.05).In multivariable regression model,male (β=0.534,P=0.003),1,25(OH)2D (β=0.582,P=0.024),creatinine (β=0.421,P=0.037),grip strength (β=0.681,P=0.001),and lg[NT-proBNP] (β=-1.760,P=0.042) were independently associated with ASM/H2 in MHD patients.Conclusion The prevalence of sarcopenia is much higher in MHD patients than in healthy people.The levels of grip strength,NT-proBNP,creatinine and 1,25(OH)2D are the important influential factors for muscle mass in MHD patients.
