Effects of cisapride on symptoms of digestive and gastrointestinal hormones in chronic renal failure patients
10.3760/cma.j.issn.1001-7097.2018.08.003
- VernacularTitle:西沙必利对慢性肾衰竭患者消化道症状及胃肠激素的影响
- Author:
Bingyue WANG
1
;
Aili JIANG
;
Chunhong LI
;
Jing XU
;
Jie TIAN
;
Su WEI
;
Kun DONG
Author Information
1. 300170,天津医科大学三中心临床学院天津市第三中心医院天津市人工细胞重点实验室卫生部人工细胞工程技术研究中心
- Keywords:
Cisapride;
Kidney failure,chronic;
Gastrointestinal hormones;
Gastrointestinal symptoms
- From:
Chinese Journal of Nephrology
2018;34(8):574-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of cisapride on symptoms of digestive and gastrointestinal hormones in chronic renal failure patients.Methods There were 46 cases of chronic renal failure patients in this paper,all patients were given routine treatment of the underlying disease and were randomly divided into two groups.23 patients were additionally treated with cisapride as research group,and the others as control group.The gastrointestinal symptoms,serum somatostatin (SS),motilin (MOT) and vasoactive intestinal peptide (VIP) and other gastrointestinal hormones and renal function in two groups of patients were compared before and after treatment.Results The score of acid reflux,nausea,vomiting,abdominal distension,belching and other symptoms of hard feces and other gastrointestinal after treatment were significantly lower than that before treatment in research group and after treatment in control group (all P ＜ 0.05).There was no significant change between before and after treatment in SS and VIP of two group (all P ＞ 0.05),and MOT in control group (P ＞0.05),but the MOT in research group was decreased significantly(P ＜ 0.05).There was no significant difference in Scr,Ccr and BUN between the control and research group after treatment (all P ＞ 0.05).Conclusion Conventional treatment combined with cisapride can improve the effect of gastrointestinal symptoms in patients with chronic renal failure,while reducing serum motilin level.
