Efficacy of low-dose leflunomide in lupus nephritis: A multi-center prospective study
10.3760/cma.j.issn.1001-7097.2018.07.006
- VernacularTitle:小剂量来氟米特诱导治疗增殖型狼疮肾炎的多中心前瞻性研究
- Author:
Chaojun QI
1
;
Minfang ZHANG
;
Yan ZHA
;
Jian CHEN
;
Ping LUO
;
Li WANG
;
Zhuxing SUN
;
Jianxin WAN
;
Changying XING
;
Song WANG
;
Gengru JIANG
;
Mindan SUN
;
Qinkai CHEN
;
Jianghua CHEN
;
Detian LI
;
Tianjun GUAN
;
Zhaohui NI
Author Information
1. 200127,上海交通大学医学院附仁济医院肾脏科
- Keywords:
Lupus nephritis;
Treatment efficacy;
Prospective study;
Leflunomide
- From:
Chinese Journal of Nephrology
2018;34(7):511-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of leflunomide combined with prednisone in the induction therapy of proliferative lupus nephritis (LN).Methods A prospective,multicenter,randomized controlled clinical trial was conducted in patients with biopsy-proved proliferative lupus nephritis recruited from 15 renal centers from 2013 to 2015.Patients were randomized to two groups.Oral leflunomide or intravenous cyclophosphamide was given to patients in each group.Both groups received a tapering course of oral prednisone therapy.All patients were followed up for 24 weeks.The blood biochemistry,urine index,clinical curative effect and adverse reaction were recorded and analyzed statistically.Results A total of 100 patients were enrolled in this clinical trial,including 48 patients in leflunomide group and 52 patients in cyclophosphamide group.After 24 weeks,the overall response rate was 79％ (95％ CI 67％-90％) in the leflunomide group and 69％ (95％ CI 56％-82％) in the cyclophosphamide group.23％ (95％CI 11％-35％) of patients in leflunomide group showed complete remission compared with 27％ (95％CI 24％-30％) in cyclophosphamide group (P=0.35).The levels of 24-hr urine protein excretion,SLEDAI and anti-dsDNA antibody titers were decreased in patients treated with leflunomide group after 24-weeks treatment.And the levels of serum albumin and complement 3 after treatment were significantly higher compared with these before treatment.There was also no significant difference in changes of 24-hr urine protein excretion,SLEDAI score,anti-dsDNA antibody titers,serum albumin and complement C3 levels after treatment between two groups.Incidence of adverse events did not differ between the leflunomide and cyclophosphamide group.Conclusions Leflunomide combined with prednisone showed same efficacy compared with cyclophosphamide as induction therapy for lupus nephritis.Leflunomide might be an useful medicine in the induction therapy of lupus nephritis.
