Risk factors for progression of aortic arch calcification in patients on maintenance hemodialysis
10.3760/cma.j.issn.1001-7097.2018.05.002
- VernacularTitle:维持性血液透析患者腹主动脉钙化进展的危险因素分析
- Author:
Zhe WANG
1
;
Fang WEI
;
Xueqing BI
;
Hongye DONG
;
Lan JIA
;
Pinghua MENG
;
Aili JIANG
Author Information
1. 300211,天津医科大学第二医院肾脏病血液净化科
- Keywords:
Calcinosis;
Aorta,Abdominal;
Hemodialysis;
Progression
- From:
Chinese Journal of Nephrology
2018;34(5):327-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible risk factors for the progression of abdominal aortic calcification (AAC) in MHD patients.Methods Total of 170 patients on MHD between June 2014 and October 2014 in the dialysis center of the Second Hospital of Tianjin Medical University were included prospectively.Lateral lumbar radiography were applied to evaluate patients' AAC score (AACs) at baseline and after two-years of follow-up respectively.According to the change of AACs,the patients were divided into rapid AAC progression group and non-rapid AAC progression group.Multivariable Logistic regression models were used to determine the risk factors for the progression of AAC in MHD patients.Results At baseline,the presence of AAC (AACs≥1) was 43.5％(74/170).The mean follow-up duration was 27.6(24.7,28.0) months.AACs were available in 111 patients,and the presence of AAC was 78.4％(87/111).During the follow up,36 patients developed new AAC;rapid AAC progression was seen in 54 patients,and non-rapid AAC progression was seen in 57 patients.Multivariate Logistic regression analysis demonstrated that hyperphosphatemia (OR=4.373,95％ CI 1.562-7.246,P=0.005) and high density lipoprotein (HDL) (OR=0.031,95％CI 0.003-0.338,P=0.004) were independent risk factors for AAC progression in MHD patients.Conclusions Hyperphosphatemia and low HDL may promote the progression of AAC.Well-controlled serum phosphate and lipid metabolism may slow the progression of vascular calcification,reducing cardiovascular morbidity and mortality.
