Clinicopathological features and outcomes of primary IgA nephropathy patients with chronic tonsillitis
10.3760/cma.j.issn.1001-7097.2017.12.001
- VernacularTitle:伴慢性扁桃体炎IgA肾病患者的临床病理特征及预后分析
- Author:
Jinfeng GUO
1
;
Xi XIA
;
Jianbo LI
;
Qian ZHOU
;
Juan XU
;
Xueqing YU
;
Qiongqiong YANG
Author Information
1. 中山大学附属第一医院肾内科
- Keywords:
Glomerulonephritis,IgA;
Tonsillitis;
Prognosis;
Cliniopathological features
- From:
Chinese Journal of Nephrology
2017;33(12):881-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinicopathological features and renal outcomes of primary IgA nephropathy (IgAN) patients with chronic tonsillitis.Methods Patients with biopsyproven primary IgAN admitted to The First Affiliated Hospital,Sun Yat-sen University from January 2006 to December 2011 were enrolled.The clinicopathological features and renal outcomes of patients with and without chronic tonsillitis were retrospectively compared.The primary outcome was progression to end stage renal diseases and/or doubling of serum creatinine.Results A total of 981 primary IgAN patients were enrolled and 98 patients (9.99％) had a history of chronic tonsillitis.Compared with patients without chronic tonsillitis,IgAN patients with chronic tonsillitis exhibited significantly higher prevalence of acute episodes of tonsillitis as a predisposition (P ＜ 0.001),higher serum IgA levels (P=0.012),and higher prevalence of macrohematuria (P=0.006).No significant difference in renal pathological features was observed in patients with and without chronic tonsillitis.Moreover,the renal outcomes were similar as regards IgAN patients with and without chronic tonsillitis.Conclusion IgAN patients with chronic tonsillitis had higher prevalence of acute episodes of tonsillitis and macrohematuria as well as higher serum IgA levels.However,IgAN patients with and without chronic tonsillitis showed no significant difference in renal pathological features and renal outcomes.
