Dyskinesia in Parkinson's disease:risk factors, diagnosis and treatment
10.3760/cma.j.issn.1006-7876.2018.12.014
- VernacularTitle:帕金森病异动症的危险因素及诊治研究进展
- Author:
Guoyong ZHANG
1
;
Yu ZHANG
;
Aijuan YAN
;
Zhenguo LIU
Author Information
1. 200092,上海交通大学医学院附属新华医院神经内科
- Keywords:
Parkinson's disease;
Dyskinesia;
Risk factors;
Diagnosis;
Treatment
- From:
Chinese Journal of Neurology
2018;51(12):1002-1007
- CountryChina
- Language:Chinese
-
Abstract:
Dyskinesia is one kind of motor complications caused by prolonged administration of levodopa to patients affected by Parkinson's disease. The mechanisms of dyskinesia in Parkinson's disease are still unknown. Recent research suggests the prevalence of dyskinesia mainly depends on genetic factors, levodopa therapy,clinical subtype, body weight and gender. Accumulating evidence indicates that assessment scales, functional magnetic resonance imaging and biomarkers could improve the clinical diagnosis and assessment of dyskinesia. In addition, a number of clinical trials of dyskinesia have indicated that new drugs such as an extended-release formulation of adamantine, and physical therapy such as repetitive transcranial magnetic stimulation are beneficial to the treatment of dyskinesia.
