The gamma-aminobutyric acid mechanism of Parkinson's central pain
10.3760/cma.j.issn.1006-7876.2018.11.014
- VernacularTitle:帕金森病中枢性疼痛的γ-氨基丁酸机制
- Author:
Yalian SHEN
1
;
Oumei CHENG
Author Information
1. 400016,重庆医科大学附属第一医院神经内科
- Keywords:
Parkinson disease;
Pain;
gamma-Aminobutyric acid
- From:
Chinese Journal of Neurology
2018;51(11):918-923
- CountryChina
- Language:Chinese
-
Abstract:
Pain is a common non-motor symptom in Parkinson's disease (PD) patients, incidence of which is high. PD patients with pain are not only prone to anxiety, depression, sleep disorders and other non-motor symptoms, but also accompanied with motor complications, causing the quality of life declined. The gamma-aminobutyric acid (GABA) neurotransmitters participate in the conduction of sensory pathways in the central nervous system. PD patients were also found that GABA regulation of the sensory pathway is impaired, indicating that GABA is also involved in the occurrence of central pain in PD. In this article we aim to elucidate the role of GABA in the central sensory pathway, and the pathological anatomy, animal anatomy, clinical image and clinical application of GABA damage in pain-related sensory pathways in PD.
