The efficacy of implant vagus nerve stimulation for intractable epilepsy
10.3760/cma.j.issn.1006-7876.2018.10.008
- VernacularTitle:植入式迷走神经刺激治疗难治性癫痫的有效性分析
- Author:
Xian WANG
1
;
Liping LI
;
Tao YU
;
Yuping WANG
;
Aihua LIU
Author Information
1. 首都医科大学宣武医院神经内科
- Keywords:
Vagus nerve stimulation;
Electric stimulation therapy;
Epilepsy;
Electroencephalography
- From:
Chinese Journal of Neurology
2018;51(10):819-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the efficacy and safety of implant vagus nerve stimulation (IVNS) for intractable epilepsy.Methods Eligible patients with intractable epilepsy during 2012-2015 were enrolled,and the information of preoperative evaluation was collected as baseline.During IVNS therapy,the process of seizures,the epileptic discharges of electroencephalogram (EEG),the complications and the changes of antiepileptic drugs or device parameters were recorded.The responder rate,the mean seizure reduction and the change of epileptic discharges were chosen as the indictors.Results Efficacy analyses were done in 33 patients,and the average age of these patients was 17.79 years.Seizure control improved over time with mean seizure reduction of 11.9％,17.3％,35.5％,38.1％,45.4％ and 50.0％,and responder rates of 18.2％(6/33),27.3％(9/33),41.4％(12/29),38.5％(10/26),7/18,and 10/17 at 1,3,6,12,24,36 months of IVNS therapy,respectively.In addition,the mean epileptic discharge reduction in EEG was 0.4％ and 13.0％,while the rate of patients who had epileptic discharge reduction of ≥50％ was 15.3％ and 23.1％ at 6,12 months of IVNS therapy,respectively.Conclusions IVNS is effective and safe.Furthermore,the efficacy of IVNS is time-dependent.
