The relationship between rs9521733 polymorphism of COL4A2 gene and lacunar stroke in Xinjiang Han populations
10.3760/cma.j.issn.1006-7876.2018.09.010
- VernacularTitle:COL4A2基因rs9521733多态性与新疆地区汉族人群腔隙性脑梗死的相关性
- Author:
Chen LIANG
1
;
Hai LIU
;
Xiaoning ZHANG
;
Jianhua MA
;
Honggang SUN
;
Jianjun DU
;
Zhiwei AN
;
Wen XIA
Author Information
1. 新疆兵团第七师医院神经内科
- Keywords:
Stroke;
COL4A2 gene;
Polymorphism,single nucleotide
- From:
Chinese Journal of Neurology
2018;51(9):717-721
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of COL4A2 gene polymorphism rs9521733 with lacunar stroke in Xinjiang Han populations.Methods A total of 406 Han lacunar stroke patients and 425 controls enrolled from the First Hospital of Xinjiang Medical University and the 7th Division Hospital of Xinjiang Production and Construction Corps between March 2016 and September 2017 were recruited in the study.Clinical data were collected from all subjects.The improved multiple ligase detection reaction method was used to analyze the genotypes of rs9521733 in the COL4A2 gene.SPSS 17.0 was used for data analysis.Results There was no statistically significant difference in genotype and allele frequency of rs9521733 between case group and control group.Stratification analyses showed that the CC genotype of rs9521733 was associated with a significant increase in risk of lacunar stroke in the group of age ≥≥60 years (adjusted OR =1.950,95％ CI 1.222-3.112,P =0.005).Conclusion The rs9521733 of the COL4A2 gene might be associated with a higher risk of lacunar stroke in the group of age ≥60 years.
