Helper T cell Th9 and its cytokine interleukin-9 in peripheral blood of patients with Parkinson's disease
10.3760/cma.j.issn.1006-7876.2018.03.003
- VernacularTitle:帕金森病患者外周血中辅助性T细胞亚群Th9及其细胞因子白细胞介素9的研究
- Author:
Yi YANG
1
;
Chenyang HAN
;
Li GUO
;
Qiaobing GUAN
Author Information
1. 314001,浙江省嘉兴市第二医院药学部
- Keywords:
Parkinson disease;
Interleukin-9;
Helper T-lymphocytes
- From:
Chinese Journal of Neurology
2018;51(3):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the proportion of helper T cell subset Th 9 and the expression of its cytokine interleukin-9(IL-9)in Parkinson's disease(PD)and the clinical significance.Methods Seventy-two patients diagnosed with PD between January 2016 and June 2017 and 20 healthy volunteers in the same period were selected.The PD patients were staged according to the Hoehn-Yahr(H-Y)staging method,21 in stage one,19 in stage two,18 in stage three,11 in stage four,and three in stage five.The proportion of Th9 subset in peripheral blood of PD patients and healthy volunteers was measured by flow cytometry.The expression of IL-9 in peripheral blood of PD patients and healthy volunteers was measured by enzyme-linked immunosorbent assay.Results The proportion of Th9 cells in peripheral blood of PD patients(1.27%±0.34%)was significantly higher than that of healthy volunteers(0.61%±0.11%,t=8.530,P<0.05),and the higher stage of PD,the higher proportion of Th9,suggesting that the proportion of Th9 was related to the PD staging.IL-9 was also highly expressed in PD patients((16.04 ±2.94) pg/ml)and had statistically significant difference compared with healthy volunteers((7.53 ±0.70)pg/ml;t=12.781,P<0.05).IL-9 was similar to Th9, the higher stage of PD, the higher expression of IL-9. Conclusion The proportion of Th9 cells and the expression of IL-9 in peripheral blood of patients with PD increased significantly,having a significant relationship with the H-Y staging of PD.
