Application of circulating tumor DNA in diagnosis and prognosis of epithelial ovarian cancer
10.3760/cma.j.issn.1671-7368.2018.12.021
- VernacularTitle:循环肿瘤DNA在上皮性卵巢癌诊断及预后评估中的应用
- Author:
Dongying WANG
1
;
Fei WU
;
Weiyang ZHANG
;
Tianmin XU
Author Information
1. 吉林大学第二医院妇产科
- Keywords:
DNA;
Neoplasm;
Ovarian neoplasms;
epithelium;
Neoplastic cells;
circulating;
Cell-free DNA;
Tumor biomarkers;
biological
- From:
Chinese Journal of General Practitioners
2018;17(12):1033-1037
- CountryChina
- Language:Chinese
-
Abstract:
In the development of cancer, the DNA fragments of tumor cells enter into the blood circulation to form circulating tumor DNA (ctDNA), which is an indicator for detecting and quantifying tumor mutations. Epithelial ovarian cancer accounts for most of the histological types in ovarian cancer. This article reviews the clinical application of ctDNA in epithelial ovarian cancer, including the early diagnosis, therapeutic effect evaluation after operation and adjuvant therapy, tumor load assessment, dynamic monitoring during the follow-up and the prognosis of patients.
