Progress on pathogenesis and treatment of adult-onset Still disease
10.3760/cma.j.issn.1671-7368.2018.10.022
- VernacularTitle:成人Still病发病机制及治疗新进展
- Author:
Mengzhu ZHAO
1
;
Min SHEN
Author Information
1. 100730,中国医学科学院 北京协和医学院 北京协和医院风湿免疫科 风湿免疫病学教育部重点实验室
- Keywords:
Still disease,adult-onset;
Autoinflammatory disease;
Pathogenesis;
Therapy
- From:
Chinese Journal of General Practitioners
2018;17(10):830-834
- CountryChina
- Language:Chinese
-
Abstract:
Adult-onset Still disease (AOSD) is a polygenic autoinflammatory disease with uncertain etiology.The clinical manifestations are complex,including high-spiking fever,rash,arthritis,arthralgia,lymphadenopathy,and leukocytosis.The pathogenesis of AOSD is still unclear,whereas it has been confirmed that many inflammatory cells and cytokines take part in the development of AOSD.The treatment of AOSD is mainly based on corticosteroids and immunosuppressive agents.Recently,with the research progress of autoinflammatory diseases and the emerging biological agents,we have new knowledge on the pathogenesis and therapeutic strategies of AOSD.This article reviews the current progress in pathogenesis and therapy of AOSD.
