Correlation of serum vitamin D and glycosylated hemoglobin levels with thyroid function in type 2 diabetes mellitus
10.3760/cma.j.issn.1671-7368.2018.10.013
- VernacularTitle:2型糖尿病患者血清维生素D、糖代谢与TSH的相关性研究
- Author:
Liyan GUO
1
;
Rongrong ZHENG
;
Dandan PENG
;
Zhijun ZHAO
;
Ling HU
Author Information
1. 山西医科大学附属人民医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
Vitamin D;
Hemoglobin A,glycosylated;
Thyroid function
- From:
Chinese Journal of General Practitioners
2018;17(10):808-810
- CountryChina
- Language:Chinese
-
Abstract:
Two hundred and seventy two type 2 diabetes mellitus (T2DM) patients with negative anti-thyroid autoantibody were enrolled in Shanxi Provincial People's Hospital from November 2016 to September 2017.According to serum vitamin D levels,patients were classified as serious deficiency of vitamin D group([25(OH)D]＜25 nmol/L,n=119),vitamin D deficiency group (≥25 ～ ＜50 nmol/L,n=124)and normal vitamin D group (≥ 50 nmol/L,n=29).There were significant differences in total T4(P=0.04),TSH (P＜0.01),parathyroid hormone (P=0.03) among these groups (P＜0.05).After adjusting gender,age,BMI,glycosylated hemoglobin (HbA1c) and duration of diabetes,serum 25(OH)D level was negatively correlated with TSH (r=-0.24,P＜0.05).After adjusting gender,age,BMI,duration of diabetes and serum 25(OH)D level,HbA1c level was negatively correlated with free T3 (r=-0.18,P＜0.01) and TSH (r=-0.20,P＜0.01).Multiple linear regression analysis revealed that TSH was correlated with 25(OH) D (β=-0.224,P＜0.01) and HbA1c (β=-0.206,P＜0.01).In conclusion,the serum vitamin D and HbA1c levels are independently correlated with thyroid function in patients with T2DM.
