Distribution and drug resistance analysis of carbapenems-resistant Klebsiella pneumoniae
10.3760/cma.j.issn.1671-7368.2018.10.009
- VernacularTitle:碳青霉烯类抗生素耐药肺炎克雷伯菌的分布及耐药性分析
- Author:
Yongchun RUAN
1
;
Yiqing ZHOU
;
Lixia YU
;
Haiwang ZHANG
;
Jianyong MA
;
Meixia SU
;
Dongfang HAN
;
Wei HE
;
Minghui LI
Author Information
1. 312000,绍兴市人民医院感染性疾病科
- Keywords:
Klebsiella pneumoniae;
Carbapenems;
Drug resistance
- From:
Chinese Journal of General Practitioners
2018;17(10):789-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical distribution and drug resistance of carbapenemsresistant Klebsiella pneumoniae (CRKP).Methods A total of 134 clinical strains of CRKP were collected from inpatients in our hospital from January 2014 to December 2016.VITEK-2 compact automatic microbiological analyzer was used to identify the bacteria and the supporting gram-negative bacterial drug susceptibility card was used for susceptibility testing.The sensitivity of other clinical commonly used antimicrobial agents was measured by K-B method.And the clinical distribution of CRKP and its resistance to antimicrobial agents were investigated and analyzed.Results The clinical strains of CRKP were isolated mainly from urine (n=70,52.2％) and sputum (n=38,28.4％).Klebsiella pneumoniae was identified in samples from the department of neurosurgery,including neurosurgery ICU (47.8％,64/134),ICU (23.9％,32/134),department of hepatobiliary surgery (8.2％,11/134) and department of urology (6.0％,8/134).Among all 22 antimicrobial agents tested,the resistant rates of CRKP to 16 antimicrobial agents were ＞90％,especially for ampicillin it was 100％,and those to 19 antibiotics were ＞80％,only for tigecycline it was 23.1％.There were 16 strains of CRKP with positive extended spectrum β-lactamases (ESBLs) (11.9％).All the CRKP strains were resistant to more than three kinds of antimicrobial agents,except one strain that was resistant to two kinds.Conclusion There is a wide range of clinical distribution of CRKP,which is resistant to most of antimicrobial agents,while tigecycline still has a strong antibacterial activity to CRKP.
