Effects of pregnancy on long-term outcomes of pulmonary arterial hypertension associated with congenital heart disease: a preliminary study
10.3760/cma.j.issn.1671-7368.2018.06.012
- VernacularTitle:妊娠对先天性心脏病相关肺动脉高压患者远期预后影响的初步研究
- Author:
Qitian OU
1
;
Jiakai LU
;
Dong YANG
;
Qing YE
;
Jie GAO
;
Limin GENG
;
Jianping SUN
;
Tengke WANG
;
Jinglan ZHANG
Author Information
1. 100029,首都医科大学附属北京安贞医院综合外科ICU
- Keywords:
Pregnancy;
Hypertension,pulmonary;
Prognosis;
Cohort studies
- From:
Chinese Journal of General Practitioners
2018;17(6):462-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of pregnancy on long-term outcomes of pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD).Methods Women with PAH-CHD who had undergone pregnancy under the care of Beijing Anzhen Hospital from 2004 to 2013 were retrospectively identified and 1∶1 matched to nulliparous PAH-CHD females (controls).Functional status and other clinical data were recorded for each group at baseline and follow-up.Results We successfully matched 40 pairs of pregnant and non-pregnant women with PAH-CHD.The patients were followed up for a mean of (6.5 ± 1.9) years,the outcomes of patients were documented during April 2016 to October 2016.No deaths occurred in either group during the study period.There were no statistically significant differences in long-term cardiac function between the two groups (Z =-1.41,P =0.16).After adjusting age,timing of follow-up,specific drug therapy and Eisenmenger's syndrome,pregnancy didn't have significant effect on the long-term deterioration of cardiac function in PAH-CHD patients (OR =1.32,95％ CI:0.33-5.37,P =0.70).Conclusion Pregnancy may not have significant effect on long-term cardiac function in PAH-CHD patients,but this conclusion needs to be confirmed by further studies.
