Effect of smoking on endothelium-dependent vascular relaxing function and plasma apelin level
10.3760/cma.j.issn.1671-7368.2018.04.012
- VernacularTitle:吸烟对血管内皮舒张功能及内源性血管活性肽的影响
- Author:
Dawei WANG
1
;
Yan FU
;
Qiumei CAO
;
Bingchen MA
;
Yixin LIU
;
Xudong WANG
Author Information
1. 100176,首都医科大学附属北京同仁医院综合内科
- Keywords:
Smoking;
Endothelium,vascular;
Dilatation;
Apelin-13 peptide
- From:
Chinese Journal of General Practitioners
2018;17(4):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of smoking on endothelium-dependent vascular relaxing function and endogenous apelin-13 level.Methods Forty healthy volunteers,including 20 smokers and 20 non-smokers were randomly selected and participated in the study from December 2014 to April 2015.During the study period the smokers were asked to quit smoking for one month and the non-smoking group was given short-term smoking intervention.The changes of vascular endothelial function and plasma apelin13 levels were compared between the smoking group and non-smoking group,and before and after intervention.Results Flow-mediated dilatation (FMD) in smoking group was significantly lower than that in non-smoking group [(5.34 ± 1.83) ％ vs.(8.12 ± 2.62) ％,t =-3.75,P ＜ 0.01].FMD in smoking group was significantly increased after 1 month of quitting smoking [(5.34 ± 1.83) ％ vs.(9.05 ± 2.18) ％,t =-6.66,P ＜ 0.01],FMD in non smoking group was slightly decreased [(8.12 ± 2.62) ％ vs.(7.78 ± 1.96) ％,t =0.90,P =0.38] after short-term smoking.The level of plasma apelin-13 in smoking group was significantly lower than that of non smoking group [(44.22 ± 16.58) pg/ml vs.(70.12 ± 24.35) pg/ml,t =-3.79,P ＜ 0.01].The level of plasma apelin-13 in smoking group was significantly increased after 1 month of smoking cessation intervention [(44.22 ± 16.58) pg/ml vs.(65.32 ± 17.13) pg/ml,t =-4.26,P ＜0.01].In non smoking group,the level of plasma apelin-13 was significantly decreased after short-term smoking [(70.12 ± 24.35) pg/ml vs.(45.83 ± 15.66) pg/ml,t =4.93,P ＜ 0.01].Conclusion Cigarette smoking leads to endothelial dysfunction.Short term occlusion of tobacco may significantly improve endothelial function and increase plasma apelin-13 level,suggesting that apelin-13 may be involved in the occurrence and development of endothelial dysfunction induced by cigarette smoking.
