Association between short-term outcomes and collateral circulation status in patients with acute ischemic stroke receiving thrombolysis therapy: a systematic review and meta-analysis
10.3760/cma.j.issn.1671-7368.2018.04.011
- VernacularTitle:急性缺血性脑卒中患者溶栓治疗短期预后与侧支循环相关性Meta分析
- Author:
Wufuer · ALIMU
1
;
Dengfeng HAN
;
Yalikun XIATIGULI·
;
Jiamaliding · HALIDAN
;
Jianhua MA
;
Xiaoning ZHANG
Author Information
1. 新疆医科大学第一附属医院神经内科
- Keywords:
Thrombolytic therapy;
Collateral circulation;
Intracranial embolism and thrombosis,acute;
Meta-analysis
- From:
Chinese Journal of General Practitioners
2018;17(4):291-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between short-term outcomes and collateral circulation status in patients with acute ischemic stroke receiving thrombolysis therapy.Methods Full-text articles published from January 2000 to November 2016 in Cochrane Library,Medline,Embase and Web of Science electronic database were retrieved and their quality was assessed.The association between short-term outcomes and collateral circulation status were analyzed by random-effects models.Results Twenty three studies involving 2 849 patients were included in quantitative synthesis.The results showed that good collateral circulations had a beneficial effect on favorable outcomes at 3 or 6 months (RR =2.26,95％ CI:1.85-2.77,P =0.00),and were also associated with a lower rate of symptomatic intracranial hemorrhage (RR =0.56,95％ CI:0.47-0.67,P ＜ 0.01) and a lower rate of mortality (RR =0.30,95％ CI:0.22-0.40,P ＜ 0.01).Conclusion The baseline collateral cimulation status is associated with the short-term outcomes in patients with acute ischemic stroke receiving thrombolysis therapy.
