The comparison between hypothermic machine perfusion and simple cold storage in chinese donation after citizen's death kidney transplantation
10.3760/cma.j.issn.0254-1785.2018.05.004
- VernacularTitle:低温机械灌注与单纯冷保存在肾移植供肾保存中效果的比较
- Author:
Qianlong LIU
1
;
Wujun XUE
;
Yang LI
;
Xiaoming DING
;
Puxun TIAN
;
Heli XIANG
;
Hang YAN
;
Xinshun FENG
;
Jun HOU
;
Xiaohui TIAN
;
Chenguang DING
Author Information
1. 710061,西安交通大学第一附属医院
- Keywords:
Kidney transplant;
Donor;
kidney;
Hypothermic machine perfusion;
Simple cold storage
- From:
Chinese Journal of Organ Transplantation
2018;39(5):276-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective Hypothermic machine perfusion may improve the outcome after transplantation of kidney donated after citizen's death (DCD),but few powered prospective studies have been reported,especially in China.The aim is to compare hypothermic machine perfusion (HMP) with simple cold storage (SCS) in Chinese DCD kidney transplantation,which can offer an optimal method for graft storage with better graft function and survival.Methods 54 kidney pairs from DCD donors were included in this controlled trial in one single center from December 2015 to March 2017.Every two kidneys from each DCD donor wavs randomly assigned to HMP and SCS group.One-year recipient and graft survival rate and endpoints containing the incidence of DGF,the duration of DGF,creatinine reduction ratio (CRR),estimated glomerular filtration rate (Egfr),primary non-function (PNF),acute rejection (AR),toxicity of the immunosuppressive drugs,nosocomial infections and the length of hospital stay were compared between HMP and SCS group.Results One-year recipient survival rate was 98.15 ％ and 96.23％ after DCD transplant in HMP and SCS group,and one-year graft survival rate was 90.74％ and 88.68％,respectively.DGF incidence was 9.62％ in total DCD kidney transplant,8.00％ in HMP group and 11.11％ in SCS group,which was no difference in two groups.22 DCD was from expanded criteria donor (ECD) donation,DGF happened in 15.91％ ECD kidney transplant.However,HMP reduced the incidence of DGF from 27.27％ to 4.55％ after ECD kidney transplant,which was significantly different (x2 =4.247,P =0.039).HMP group acquired significantly lower creatinine level (130.95 ± 46.60) μmol/L than SCS group (181.64 ± 72.94) μmol/L on day 14 after ECD transplant (t =-2.686,P =0.011).Conclusion There was a higher recipient and graft survival rate after DCD and ECD kidney transplant,which would be an effective method to expand donor pool for kidney transplant.HMP was not associated with lower DGF rate in DCD kidney transplant and more rapid recovery in early graft function.However,HMP preservation not only made renal function recover more rapidly but reduced the risk of DGF after ECD kidney transplant.
