Long-term clinical efficacy of simplified multivisceral transplantation from donation after citizen's death
10.3760/cma.j.issn.0254-1785.2017.12.003
- VernacularTitle:器官捐献上腹部多器官移植长期疗效分析
- Author:
Weiqiang JU
1
;
Zhuohui LI
;
Wei ZHANG
;
Zhiyong GUO
;
Ming HAN
;
Xiaoping WANG
;
Maogen CHEN
;
Yi MA
;
Dongping WANG
;
Xiaofeng ZHU
;
Xiaoshun HE
Author Information
1. 中山大学附属第一医院器官移植中心
- Keywords:
Multivisceral transplantation;
Liver transplantion;
Pancreas transplantation;
Duodenum;
Diabetes mellitus,type 2;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2017;38(12):714-718
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the long-term clinical efficacy of simplified multivisceral transplantation in patients with end-stage liver disease and type 2 diabetes.Methods The clinical data of 31 cases of simplified multivisceral transplantations between 2009 to 2017 were retrospectively analyzed.Results Median post-transplant follow-up was currently 13 ± 26 (0-86) months.Two recipients died of multiple organ dysfunction system (MODS) followed by severe sepsis on postoperative day (POD) 15 and 18,respectively.One recipient died from severe pneumonia with pyemia on POD 37.One recipient died of graft versus host disease (GVHD) on POD 40.One recipient died from acute myelogenous leukemia.Two recipients died of tumor recurrence at postoperative month (POM) 9 and 26,respectively.No biliary complication or diabetes recurrence was observed during follow-up.Condusion Donation after citizen's death is becoming the only organic source in China.Our results indicate that combined en-bloc liver-pancreas transplantation is technically feasible and leads to excellent long-term control of glucose metabolism and satisfactory quality of life in recipients with end—stage liver disease and diabetes mellitus.
