Donor-related risk factors of long-term biliary complications after liver transplantation from organ donation by citizens after death
10.3760/cma.j.issn.0254-1785.2017.11.003
- VernacularTitle:公民逝世后器官捐献供肝移植术后远期胆道并发症供者相关危险因素分析
- Author:
Qing YANG
1
;
Binsheng FU
;
Yi ZHANG
;
Shijie GU
;
Yingcai ZHANG
;
Wei LIU
;
Tong ZHANG
;
Huimin YI
;
Shuhong YI
;
Genshu WANG
;
Hua LI
;
Yang YANG
;
Guihua CHEN
Author Information
1. 中山大学附属第三医院肝脏外科
- Keywords:
Liver transplantation;
Tissue donation;
Biliary complication;
Risk factors
- From:
Chinese Journal of Organ Transplantation
2017;38(11):649-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the donor-related risk factors for long-term biliary complications after liver transplantation (LT) from organ donation by citizens after death.Methods The clinical data of 140 donors who donated the organs after death for LT in the Third Affiliated Hospital of Sun Yat-sen University between April 2016 and April 2017 were retrospectively analyzed.The incidence of long-term biliary complications after LT in the recipients was observed,and the relationship between the incidence and the clinical indexes of the donors was analyzed.The influencing factors for long-term biliary complications after LT were analyzed using univariate and multivariate logistic regression analysis.Results The incidence of long-term biliary complications after LT in the recipients was 9.29％ (13/140).The incidence of donation after cardiac death (DCD) group and donation after brain death (DBD) group was 9.68％ (6/62) and 8.97％ (7/78) respectively.There was no significant difference between the two groups.Univariate logistic regression analysis revealed the long-term biliary complications after LT was related with cerebrovascular accident cause,the second warm ischemia time,steatosis of liver,history of cardiopulmonary resuscitation,dosage of dopamine before procurement and hypoproteinemia.Multivariate logistic regression analysis (removing warm ischemia time) revealed the independent influencing factors for long-term biliary complications after LT from organ donation were the second warm ischemia time (OR =1.106,95％ CI:1.034-1.181;P＜0.05),steatosis of liver (OR =5.319,95％ CI:1.020-27.752;P＜0.05) and dosage of dopamine before procurement (OR =1.279,95％ CI:1.021-1.601;P ＜ 0.05).Conclusion Postoperative long-term biliary complication is one of the major complications after LT from organ donation.The independent risk factors should be strictly controlled,as the second warm ischemia time,steatosis of liver and dosage of dopamine before procurement are contributed to the incidence of long-term biliary complications.
