Expression and clinical significance of LKB1 and PTEN in hepatocellular carcinoma
10.3760/cma.j.issn.1007-631X.2018.05.016
- VernacularTitle:LKB1和PTEN在肝细胞癌中的表达及临床意义
- Author:
Xingang ZHOU
1
;
Jiamin CHEN
;
Haili GAO
;
Man LI
;
Kun YANG
;
Zhiyuan MA
;
Peng WANG
Author Information
1. 100015,首都医科大学附属北京地坛医院病理科北京市中西医结合感染性疾病研究所
- Keywords:
Carcinoma,hepatocellular;
Gene expression;
Liver kinase B1;
Phosphatase and tensin homology deleted on chromosome ten
- From:
Chinese Journal of General Surgery
2018;33(5):420-424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of liver kinase B1 (LKB1) and phosphatase and tensin homology deleted on chromosome ten (PTEN) in hepatocellular carcinoma (HCC) and their relationship with pathological characteristics and prognosis of HCC.Methods hnmunohistochemistry was used to detect expression of LKB1 and PTEN in 115 HCC cases.The relationship between clinicopathologic factors and the expressions was analyzed.Results The positive expression rate of LKB1 and PTEN was 10.4％ (12/115) and 28.7％ (33/115) respectively.The coexpression ratio of LKB1 and PTEN was 5.2％ (6/115).LKB1 and PTEN double deletion rate was 66.1％,with the latter most often found in those ≥ 50 years of age group (x2 =7.968,P =0.001),middle low differentiation HCC group (x2 =11.297,P =0.025) and vascular tumor thrombus group (x2 =6.797,P =0.011).The 5 year survival rates of LKB1 and PTEN protein coexpression and double deletion patients were 100％ and 36.5％ (x2 =10.969,P =0.004),respectively.Multivariate COX regression analysis showed that vascular tumor thrombus,PTEN deletion and LKB1/PTEN double deletion were independent risk factors for the prognosis of HCC.Condusions Double deletion of LKB1/PTEN protein is one of the independent factors that affect the survival time of HCC patients.
