Transition analysis in the clinicopathology and prognosis of 2 682 papillary thyroid carcinoma cases over a 15-year period
10.3760/cma.j.issn.1007-631X.2018.05.009
- VernacularTitle:2682例甲状腺乳头状癌临床病理及预后分析
- Author:
Weibin WANG
1
;
Xingyun SU
;
Jiaying RUAN
;
Zhuochao MAO
;
Kuifeng HE
;
Min WANG
;
Fusheng WU
;
Donghui ZHOU
;
Jianming SHENG
;
Zhongqi LI
;
Xiongfei YU
;
Yimin LU
;
Haiyong WANG
;
Xiaodong TENG
;
Wenhe ZHAO
;
Zhimin MA
;
Lisong TENG
Author Information
1. 浙江大学医学院附属第一医院肿瘤中心
- Keywords:
Thyroid neoplasms;
Carcinoma,papillary;
Pathology,clinical;
Prognosis;
Lymph node metastasis
- From:
Chinese Journal of General Surgery
2018;33(5):393-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the change of clinicopathological features and prognosis of papillary thyroid cancer over a 15-year period.Methods The clinicopathological features and outcomes of papillary thyroid cancer patients were analyzed in three groups according to the time of diagnosis:group Ⅰ (1997-2001),group Ⅱ (2002-2006),and group Ⅲ (2007-2011).Results As time advanced,the average age of papillary thyroid cancer patients increased,tumor stage,like size,extrathyroid invasion and lymph node metastasis decreased dramatically (P ＜ 0.01).The percentage of multifocality and bilaterality increased.The long-term follow up data (median follow up time was 6.6 years),indicated that the 15-year over all survival was 97.8％ and the 15-year disease-free survival was 90.2％.Tumor ≥3 cm,bilaterality,extrathyroid invasion,lymph node metastasis and AJCC stage were correlated with tumor recurrence.By multivariate COX-regression analysis only lymph node metastasis and bilaterality were independent risk factors.Conclusion The clinicopathological features of papillary thyroid cancer changed over 15 years,with the percentage of early-staged patients increased.Lymph node metastasis and bilaterality are two risk factors for tumor recurrence.
