Expression of PGE2 and COX-2 in colorectal cancer and the clinical significance
10.3760/cma.j.issn.1007-631X.2018.04.014
- VernacularTitle:前列腺素E2和环氧化酶2在结直肠癌组织中的表达及其临床意义
- Author:
Jiachi MA
1
;
Xiaodan ZHAO
;
Jianbo QI
;
Qingjin GUO
;
Zhenqiang GONG
;
Jianbo DU
;
Xiaochang CHEN
Author Information
1. 甘肃省人民医院普通外科
- Keywords:
Colorectal neoplasms;
Dinoprostone;
Cyclooxygenase 2;
Prognosis
- From:
Chinese Journal of General Surgery
2018;33(4):322-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of PGE2 and COX-2 between colorectal cancer tissue and normal colorectal mucosa tissue,and its relation to clinical pathology and significance.Methods 115 colon cancerous tissues and 69 normal colon tissues were collected in our hospital from Jan 2010 to Sept 2011.Immunohistochemistry was used to detect the PGE2 and COX-2 expression in both of the colorectal cancer and normal tissues.Results Positive expressions of PGE2 and COX-2 were 87.8％ (101/115) and 80.9％ (93/115) in the colorectal cancer tissue,and 8.7％ (6/69),21.7％ (15/69) in normal colorectal mucosa tissue respectively (x2 =110.96,62.194,all P ＜ 0.05).Expressions of PGE2 and COX-2 were closely associated with,tumor invasion,differentiation,lymph node metastasis and TNM stage (P ＜ 0.05).The Spearman rank correlation analysis indicated that the PGE2 and COX-2 expressions in tissues were closely correlated (r =0.987,P ＜ 0.05).Survival rate of the patients in both negative expressions of PGE2 and COX-2 (63.6％) were higher than that of both positive expressions (37.8％,P ＜ 0.05).Conclusion High PGE2 and COX-2 expressions in colorectal cancer tissues predicts poor patients' survival.
