Thrombelastography in evaluating effect of antiplatelet drugs for patients undergoing peripheral endovascular treatment and relationship with ischemic-events-free duration
10.3760/cma.j.issn.1007-631X.2018.02.008
- VernacularTitle:血栓弹力图检测抗血小板药物疗效与下肢动脉腔内治疗后再缺血关系的研究
- Author:
Jifu LAI
1
;
Wenna XU
;
Guangwei YANG
;
Cong YU
;
Chao WEN
;
Jinsong JIANG
Author Information
1. 浙江省人民医院血管外科
- Keywords:
Thromboelastography;
Platelet aggregation inhibitors;
Peripheral arterial disease;
Endovascular treatment
- From:
Chinese Journal of General Surgery
2018;33(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of antiplatelet drugs and ischemic-events-free duration by thromboelastography (TEG) in patients undergoing peripheral endovascular treatment.Methods From Mar 2015 to Oct 2016,38 patients undergoing initial successful peripheral stenting and then coming back for recurrent ischemic events.TEG was used to evaluate the platelet inhibition rate induced by arachidonic acid (AA％) approach,the platelet inhibition rate induced by adenosine diphosphate (ADP％) approach,and the ADP-induced platelet-fibrin clot strength (MAADP).Clinical feature differences between patients with MAADP ＞ 47 mm and MAADP ≤ 47 mm were compared.Results AA％ less than 50％ was found in 9 patients(23.9％),and ADP％ less than 30％ in 14 patients(36.8％).5 patients met the two conditions.Patients with MAADp ＞ 47 mm had a significantly lower ADP％ (x2 =10.755,P ＜ 0.001),compared to patients with MAADP ≤47 mm.Univariate survival analysis showed ADP％ ＜ 30％ and MAADP ＞47 mm were risk factors for getting shorter ischemic-events-free duration,compared to patients with ADP％ ≥ 30 (P ＜ 0.001),with MAADP ≤47 mm (x2 =4.408,P =0.036).Conclusions TEG may detect those patients who has a low response to antiplatelet drugs,and some TEG parameters may have a ischemic predictive value.
