Clinicopathological features and prognostic factors in gastric hepatoid adenocarcinoma
10.3760/cma.j.issn.1007-631X.2018.01.004
- VernacularTitle:胃肝样腺癌临床病理特征及预后分析
- Author:
Weigang DAI
1
;
Dawei LIU
;
Hui WU
;
Liang WANG
;
Yulong HE
;
Shirong CAI
;
Chuangqi CHEN
Author Information
1. 中山大学附属第一医院胃肠外科中心 中山大学胃癌诊治中心
- Keywords:
Stomach neoplasms;
Alpha-fetoproteins;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2018;33(1):11-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological characteristics and prognostic factors of hepatoid adenocarcinoma of the stomach (HAS).Methods From Jan 2006 to Jan 2016,the clinical pathological data of 15 HAS cases in our hospital were analyzed retrospectively.60 TNM stage matched cases of non-HAS gastric cancer served as the control group.The clinical pathology factors and prognosis were compared between the two groups.Results Serum AFP positive HAS patients accounted for 87％.The serum level of AFP in HAS were significantly higher than that in controls (P ＜0.001).HAS was more prone to lymphatic invasion (73％ vs.33％,x2 =7.918,P =0.005) and vascular invasion (40％ vs.10％,x2 =8.036,P =0.005) than control gastric cancer.The immunohistochemistry positive rates of AFP,Glypican3,Hepatocyte and CEA in HAS were 87％,87％,33％,53％ respectively.Liver metastasis (53％ vs.12％,P =0.001) and other distant metastases (53％ vs.15％,P =0.004) were higher in the HAS.HAS median survival time was significantly lower (28.0 months vs.50.7 months,x2 =4.350,P =0.037).Postoperative HAS 1,3 and 5 years survival rates were 80％,33％ and 20％,respectively,significantly worse than 97％,78％ and 33％ in control group (x2 =5.525,17.198,5.472,P =0.019,0.000,0.019 respectively).The independent risk factor influencing the prognosis of HAS included TNM stage,vascular invasion,distant metastasis.Conclusions HAS is often complicated with higher serum AFP and prone to vascular invasion,lymph node metastasis and distant metastasis,hence a poorer prognosis.
