Effect of FTO gene on type 2 diabetes mellitus treated by Roux-en-Y gastric bypass
10.3760/cma.j.issn.1007-631X.2017.12.019
- VernacularTitle:FTO基因对Roux-en-Y胃旁路术治疗2型糖尿病疗效的影响
- Author:
Dexiao DU
1
;
Ke GONG
;
Bin ZHU
;
Dongbo LIAN
;
Qing FAN
;
Guangzhong XU
;
Nengwei ZHANG
Author Information
1. 100038,首都医科大学附属北京世纪坛医院普外科
- Keywords:
Diabetes mellitus,type 2;
Polymorphism,single nucleotide;
Anastomosis,Roux-en-Y;
Laparoscopy
- From:
Chinese Journal of General Surgery
2017;32(12):1050-1053
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of FTO gene on laparoscopic Roux-en-Y gastric bypass for type 2 diabetes.Methods From Jan 2014 to 2015 Jun,32 T2DM patients received LRYGB in Beijing Shijitan Hospital.According to single nucleotide polymorphism of FTO rs9939609 gene,patients were divided into TF genotype (20 cases),and AT/AA genotype (12 cases).Results Following the degression of BMI from (36.4 ±3.3) kg/m2 to (28.1 ±2.8) kg/m2,fasting blood glucose and HbA1c in group A significantly improved [(8.9 ± 1.6) mmol/L vs.(5.6 ± 1.2) mmol/L,t =8.274,P =0.000;(8.5％ ± 1.9％) vs.(6.2％ ± 0.8％),t =5.032,P =0.000].Following the degression of BMI from (39.5 ±5.6) kg/m2 to (29.7 ± 5.1) kg/m2,fasting blood glucose and HbA1c in group B significantly improved [(10.8 ± 2.8) mmol/L vs.(4.9 ± 0.6) mmol/L,t =7.589,P =0.000;(9.0％ ± 1.8％) vs.(6.1％ ±0.9％),t =5.324,P =0.000].Insulin resistance index in both groups significantly improved [(12.6±10.7) vs.(4.9±5.6),t=5.402,P=0.000;(16.0±5.6) vs.(1.7±1.3),t=9.025,P=0.000].Fasting blood glucose and the insulin resistance index in group B patients was significantly lower than that in group A patients (P ＜ 0.05).Conclusion T2DM patients with FTO rs9939609 gene phenotype AT/AA have better prognosis than those with TT in postoperative diabetes improvement.
