Influence of hyperthermic intraperitoneal perfusion chemotherapy on cellular immune function in esophagogastric junction adenocarcinoma after radical resection

VernacularTitle:食管胃交界部腺癌术后腹腔热灌注化疗对细胞免疫的影响
Author: Shoumiao LI ¹ ; Zhizhong ZHANG ; Wei ZHANG ; Zhiqiang LIU ; Baozhong LI ; Yunjie WAN ; Ganshu XIA
Author Information

1. 安阳市肿瘤医院外科
Keywords: Stomach neoplasms; Chemotherapy,cancer,regional perfusion; Taxoids; Cellular immune
From: Chinese Journal of General Surgery 2017;32(12):1047-1049
CountryChina
Language:Chinese
Abstract: Objective To evaluate T lymphocyte changes in esophagogastric junction adenocarcinoma (AEGJ) patients receiving early hyperthermic intraperitoneal perfusion chemotherapy (HIPEC) after radical resection.Methods 98 AEGJ cases were randomized into postoperative early paclitaxel HIPEC group (50 cases) and surgery only group (48 cases).The changes in TLC,CD3 +,CD4 +,CD8 + and CD4 + CD25 + were examined by using flow cytometry on the preoperaive d1,and on the postoperative d 9.Results There were significant differences in cellular ratios of TLC,CD3 +,CD4 +,CD8 + and CD4 + CD25 + between the two groups on postoperative d 9 [(1.85 ± 0.36) × 109/L,(1.28 ± 0.28) ×109/L,t=8.727,P＜0.001;76％ ±6％,65％ ±6％,t =8.680,P＜0.001;57％ ±8％,41％ ± 7％,t =10.246,P ＜0.001:20％ ±7％,25％ ±6％,t =4.037,P ＜0.001;4.2％ ±1.8％;6.7％ ± 2.0％,t =6.548,P ＜ 0.001].Conclusion Postoperative early HIPEC using paclitaxel improves the celluar immune activity of T cell subsets in advanced AEGJ patients.